Associations of Prenatal Mercury Exposure From Maternal Fish Consumption and Polyunsaturated Fatty Acids With Child Neurodevelopment: A Prospective Cohort Study in Italy

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概要

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• Background: Mercury is a neurotoxin, and limited prenatal exposure to it can affect long-term child neurodevelopment. However, results of epidemiologic studies of such exposure have been inconsistent. We examined the association of prenatal mercury exposure from maternal fish consumption with child neurodevelopment in northern Italy.<BR>Methods: A population-based cohort of 606 children and their mothers was studied from pregnancy to age 18 months. Mercury levels were measured in maternal hair and blood during pregnancy and in umbilical cord blood and breast milk. Levels of polyunsaturated fatty acids (PUFAs) were measured in maternal serum. Maternal and child intakes of fish were assessed by using a food frequency questionnaire. The Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) was used to evaluate child neurodevelopment. Multivariate linear regression was used to examine the association of mercury exposure with BSID-III scores, after controlling for maternal fish intake, PUFAs during pregnancy, and several other confounders.<BR>Results: Mean weekly fish intake during pregnancy was less than 2 servings. Mercury concentrations in biological samples were low (mean, 1061 ng/g in hair) and moderately correlated with fish intake, particularly of carnivorous species. Maternal ω-3 PUFA concentrations were poorly correlated with fish intake. Maternal intelligence quotient (IQ) and child intake of fish were significantly associated with neurodevelopment scores. In multivariate models, the level of Hg exposure was not associated with neurodevelopmental performance at 18 months.<BR>Conclusions: In this Italian population, neurodevelopment at 18 months was associated with child intake of fresh fish and maternal IQ rather than with mercury exposure. The expected beneficial effect of maternal fish intake (from maternal ω-3 PUFAs) was not found.

著者

• Horvat Milena

  Jozef Stefan Institute

• Valent Francesca

  Institute Of Hygiene And Clinical Epidemiology University Hospital Of Udine

• MAZEJ Darja

  Jozef Stefan Institute

• Barbone Fabio

  Institute Of Hygiene And Clinical Epidemiology University Hospital Of Udine

• McAfee Alison

  School of Biomedical Sciences, University of Ulster

• Mariuz Marika

  Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences (DSMB), University of Udine

• Tamburlini Giorgio

  Institute for Maternal and Child Health-IRCCS Burlo Garofolo

• Mariuz Marika

  Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences, University of Udine

• Bin Maura

  Division of Child Neuropsychiatry, Institute for Maternal and Child Health-IRCCS Burlo Garofolo

• Tognin Veronica

  Division of Child Neuropsychiatry, Institute for Maternal and Child Health-IRCCS Burlo Garofolo

• Tratnik Janja

  Jozef Stefan Institute

• Mulhern Maria

  School of Biomedical Sciences, University of Ulster

• Parpinel Maria

  Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences, University of Udine

• Carrozzi Marco

  Division of Child Neuropsychiatry, Institute for Maternal and Child Health-IRCCS Burlo Garofolo

関連論文

• Maternal Diet and Selenium Concentration in Human Milk From an Italian Population
• Neurodevelopmental Effects of Low-level Prenatal Mercury Exposure From Maternal Fish Consumption in a Mediterranean Cohort: Study Rationale and Design
• Associations of Prenatal Mercury Exposure From Maternal Fish Consumption and Polyunsaturated Fatty Acids With Child Neurodevelopment: A Prospective Cohort Study in Italy
• Neurodevelopmental Effects of Low-level Prenatal Mercury Exposure From Maternal Fish Consumption in a Mediterranean Cohort : Study Rationale and Design

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