Neurodevelopmental Effects of Low-level Prenatal Mercury Exposure From Maternal Fish Consumption in a Mediterranean Cohort: Study Rationale and Design

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概要

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• Background: Mercury is a neurotoxic environmental pollutant. However, the literature on the neurodevelopmental effect of low-level prenatal mercury exposure from maternal fish intake is inconsistent. We assessed the association between prenatal mercury exposure and infant neurodevelopment in coastal areas of 4 Mediterranean countries.<BR>Methods: This was a prospective cohort study that planned to enroll approximately 1700 mother–infant pairs. Pregnant women and their newborn children were recruited in selected hospitals of the study areas. Biological samples, including maternal hair and cord blood, were collected from mothers and children, and the concentrations of mercury and other elements were measured. Exposures to lifestyle, environmental, and social factors were assessed through questionnaires. The main outcome was child neurodevelopment at 18 months, as measured by the Bayley Scales of Infant and Toddler Development, Third Edition.<BR>Conclusions: This cohort has a number of strengths. First, mercury concentration was measured in several biological samples, which allows for a better understanding of mercury kinetics and is useful for sensitivity analyses. Therefore, we expect to be able to adjust for the potential confounding effects of lifestyle and social factors and for the effects of other elements that were measured in the biological samples. Finally, this is a multinational study and thus permits assessment of the relation between mercury and child neurodevelopment in different populations.

著者

• Horvat Milena

  Jozef Stefan Institute

• Valent Francesca

  Institute Of Hygiene And Clinical Epidemiology University Hospital Of Udine

• MAZEJ Darja

  Jozef Stefan Institute

• Barbone Fabio

  Institute Of Hygiene And Clinical Epidemiology University Hospital Of Udine

• Sofianou-Katsoulis Aikaterini

  Institute of Child Health

• Spiric Zdravko

  OIKON Ltd, Institute for Applied Ecology

• Prasouli Alexia

  Institute of Child Health

• Mariuz Marika

  Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences (DSMB), University of Udine

• Tamburlini Giorgio

  Institute for Maternal and Child Health-IRCCS Burlo Garofolo

• Nakou Sheena

  Institute of Child Health

• Little D'Anna

  Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences (DSMB), University of Udine

関連論文

• Maternal Diet and Selenium Concentration in Human Milk From an Italian Population
• Neurodevelopmental Effects of Low-level Prenatal Mercury Exposure From Maternal Fish Consumption in a Mediterranean Cohort: Study Rationale and Design
• Associations of Prenatal Mercury Exposure From Maternal Fish Consumption and Polyunsaturated Fatty Acids With Child Neurodevelopment: A Prospective Cohort Study in Italy
• Neurodevelopmental Effects of Low-level Prenatal Mercury Exposure From Maternal Fish Consumption in a Mediterranean Cohort : Study Rationale and Design

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