Epidemiology and Clinical Characteristics of Congenital Hypothyroidism in an Asian Population: A Nationwide Population-Based Study
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概要
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Background: The incidence of congenital hypothyroidism (CH) has been increasing in Western countries, and some populations, including Asians, have a higher incidence. Delayed diagnosis and early treatment influence the outcome of CH. We investigated the incidence and clinical characteristics of CH in Taiwan.<BR>Methods: In this retrospective database study we identified cases of CH diagnosed during 1997–2008 in the Taiwan National Health Insurance Research Database (NHIRD). Patients who had a Serious Accidents and Diseases certificate were included in the incidence calculation. We focused on CH patients who were born during 1997–2003 and determined their age at diagnosis and CH-related clinical features. Mental retardation and physiological delays were evaluated with respect to age at diagnosis.<BR>Results: A total of 1482 cases were identified. Incidence during the 12-year period was 5.02 per 10 000 births. Among 1115 patients, the most common clinical features of CH were developmental delay (9.6%), constipation (11.6%), and delayed physiological development (9.1%). Congenital anomalies of the heart (7.7%), epilepsy (2.7%), and infantile cerebral palsy (3.2%) were also noted. Survival analysis showed that the risks of mental retardation (hazard ratio [HR], 3.180) and delayed physiological development (HR, 1.908) were greater when age at diagnosis was greater than 1 year.<BR>Conclusions: CH incidence was higher in Taiwan than in Western countries. Early diagnosis may decrease the risk of mental and physiological delay.
著者
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Huang Yaw-bin
Graduate Inst. Of Clinical Pharmacy Kaohsiung Medical Univ.
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Lai Wen-Ter
Department of Internal Medicine, College of Medicine, Kaohsiung Medical University
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Lee Charles
Department of Public Health, Kaohsiung Medical University
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Lee Kun-Tai
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital
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Lee Kun-Tai
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University
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Chen Chung-Yu
School of Pharmacy, Kaohsiung Medical University
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