Modulation of the Expression of Long-Term Cardiac Memory by Short-Term Cardiac Memory in Patients With Wolff-Parkinson-White Syndrome After Catheter Ablation

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Background The interaction between long- and short-term cardiac memory(CM) is unknown. Methods and Results The T-wave areas and QTc intervals in each ECG lead were analyzed in 11 patients with manifest Wolff-Parkinson-White syndrome with posterior or septal accessory pathway(4 females; mean age: 47±12 years) in the following ECGs:(1) immediately after catheter ablation(post-ablation ECG);(2) immediately after 20 min of right ventricular outlet pacing(post-pacing ECG); and(3) 1 week after ablation(recovery ECG). Compared with the post-ablation ECGs, the T-wave areas of the recovery ECGs in leads II and aV_F changed dramatically from negative to positive while that in lead III became less negative(p<0.01), and those in leads I, aVt, and V_<2-4> became less positive(p<0.05). Compared with the post-ablation ECGs, the T-wave areas of the post-pacing ECGs in leads El and aVp became less negative(p<0.01), and those in leads I, aV_L, and V_<2-4> became less positive(p<0.05). The QTc interval in the post-ablation ECG was significantly longer than in either the post-pacing or recovery ECGs(p<0.05). Conclusions Mechanisms involved in the expression of long-term CM could be affected by short-term CM.
社団法人日本循環器学会の論文
2007-02-20