A 39-kDa Capsular Protein Is a Major Cross-Protection Factor Demonstrated by Protection of Chicken with a Live Attenuated Pasteurella multocida Strain P-1059

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概要

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• The aim of this study was to state that a 39-kDa protein or OmpH of Pasteurella multocida strain P-1059 is essential for cross protection. Strain PBA322, a low capsulated strain of P. multocida strain P-1059, was performed as a live vaccine in chickens. Strain PBA322 is a low capsulated strain in comparison with a parental strain P-1059. Chickens were vaccinated by single injection and then challenge-exposed with strains P-1059 or X-73 at two-week post vaccination. Moreover, immune responses were also evaluated for both humoral and cellular immune response by ELISA and lymphocyte proliferation assay, respectively. The results showed that the live vaccine induced efficient immunity to protect chicken from challenge-exposure with parent strain but heterologous protectivity was poor. This concluded that the 39-kDa protein is essential for a cross protection.

著者

• KATAOKA Yasushi

  Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University

• Sawada Takuo

  Laboratory Of Microbiology Faculty Of Veterinary Medicine Nippon Veterinary And Life Sciences Univer

• STHITMATEE Nattawooti

  Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

• YANO Terdsak

  Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

• LAMPANG Kannikar

  Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand

• SUPHAVILAI Chaisuree

  Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50100, Thailand

• SAWADA Takuo

  Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University, Musashino, Tokyo 180–8602, Japan

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• A 39-kDa Capsular Protein Is a Major Cross-Protection Factor Demonstrated by Protection of Chicken with a Live Attenuated Pasteurella multocida Strain P-1059

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