Volumetric Characterization of Human Coronary Calcification by Frequency-Domain Optical Coherence Tomography

スポンサーリンク

概要

• 論文の詳細を見る

• Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy of intravascular FD-OCT to determine the distribution of CAC. Methods and Results: Cadaveric coronary arteries were imaged using FD-OCT at 100-μm frame interval. Arteries were subsequently frozen, sectioned and imaged at 20-μm intervals using the Case Cryo-Imaging automated systemTM. Full volumetric co-registration between FD-OCT and cryo-imaging was performed. Calcium area, calcium-lumen distance (depth) and calcium angle were traced on every cross-section; volumetric quantification was performed offline. In total, 30 left anterior descending arteries were imaged: 13 vessels had a total of 55 plaques with calcification by cryo-imaging; FD-OCT identified 47 (85%) of these plaques. A total of 1,285 cryo-images were analyzed and compared with corresponding co-registered 257 FD-OCT images. Calcium distribution, represented by the mean depth and the mean calcium angle, was similar, with excellent correlation between FD-OCT and cryo-imaging respectively (mean depth: 0.25±0.09 vs. 0.26±0.12mm, P=0.742; R=0.90), (mean angle: 35.33±21.86° vs. 39.68±26.61°, P=0.207; R=0.90). Calcium volume was underestimated in large calcifications (3.11±2.14 vs. 4.58±3.39mm3, P=0.001) in OCT vs. cryo respectively. Conclusions: Intravascular FD-OCT can accurately characterize CAC distribution. OCT can quantify absolute calcium volume, but may underestimate calcium burden in large plaques with poorly defined abluminal borders.

著者

• Wilson David

  Department Of Anatomy School Of Medicine The Queen's University Of Belfast

• Wang Wei

  Harrington Mclaughlin Heart And Vascular Institute University Hospitals Case Medical Center And Case

• Mehanna Emile

  Harrington Mclaughlin Heart And Vascular Institute University Hospitals Case Medical Center And Case

• Bezerra Hiram

  Harrington Mclaughlin Heart And Vascular Institute University Hospitals Case Medical Center And Case

• Tahara Satoko

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Costa Marco

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Kanaya Tomoaki

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Prabhu David

  Department of Biomedical Engineering, Case Western Reserve University

• Brandt Eric

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Chamié Daniel

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Yamamoto Hirosada

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Attizzani Guilherme

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Van Ditzhuijzen

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Fujino Yusuke

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Stefano Gregory

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Gargesha Madhusudhana

  Department of Biomedical Engineering, Case Western Reserve University

• Bezerra Hiram

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Wang Wei

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

• Mehanna Emile

  Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University

関連論文

• Selective Cadmium Accumulation Using Recombinant Escherichia coli (Environmental Biotechnology)
• Astrocytoma with pilomyxoid features presenting in an adult
• A Rho-dependent actin purse-string is involved in wound repair in the early chick amnion following surgical puncture
• Phosphorescent probes for oxygen measurements in vivo
• Impact of Acute Gain on Clinical Outcomes of Patients Treated With Sirolimus-Eluting Stent : A Sub-Analysis Study From the STLLR Trial
• Volumetric Characterization of Human Coronary Calcification by Frequency-Domain Optical Coherence Tomography

スポンサーリンク