Four New 7,8-Epoxycembranoids from a Chinese Soft Coral Lobophytum sp.

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概要

• 論文の詳細を見る

• Four new 7,8-epoxycembranoids, namely (2S*,7S*,8S*,12R*,1Z,3E,10E)-7,8:2, 16-diepoxycembra-1(15),3,10-trien-12-ol (1), (2S*,7S*,8S*,11R*,1Z,3E)-7,8:2,16-diepoxycembra-1(15),3,12(20)-trien-11-ol (2), (4S*,7S*,8S*,1Z,2E,11E)-16-acetoxy-7,8-epoxycembra-1(15),2,11-trien-4-ol (3), and (7S*,8S*,15S*,1E,3E,11E) -7,8-epoxycembra-1,3,11-trien-15,16-diol (4) were isolated from a Chinese soft coral Lobophytum sp., together with eleven known analogues 5–15. The structures of the new compounds were determined by extensive spectroscopic data analysis. All compounds were tested for the inhibitory effect on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages (PEMΦ).

著者

• Zhao Feng

  School Of Engineering And Computer Science Washington State University

• Xiang Zheng

  School of Pharmacy, Wenzhou Medical University

• Zhao Min

  School of Pharmacy, Wenzhou Medical University

• Li Xiubao

  Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences

• Cheng Shimiao

  School of Pharmacy, Wenzhou Medical University

• Dong Jianyong

  School of Pharmacy, Wenzhou Medical University

• Huang Kexin

  School of Pharmacy, Wenzhou Medical University

• Yan Pengcheng

  School of Pharmacy, Wenzhou Medical University

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