Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles
スポンサーリンク
概要
- 論文の詳細を見る
A new class of sulfonamidomethane pyrrolyl–oxadiazoles/thiadiazoles and pyrazolyl–oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.
著者
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Padmavathi Venkatapuram
Department Of Chemistry Sri Venkateswara University
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Padmaja Adivireddy
Department Of Chemistry Sri Venkateswara University
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Reddy Sanapalli
Department of Chemistry, Pusan National University
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Reddy Sanapalli
Department of Chemistry, Sri Venkateswara University
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Kondaiah Paturu
Department of Molecular Reproduction Development and Genetics, Indian Institute of Science
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Swapna Mukkara
Department of Chemistry, Sri Venkateswara University
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Krishna Narra
Department of Molecular Reproduction Development and Genetics, Indian Institute of Science
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Premakumari Chokkappagari
Department of Chemistry, Sri Venkateswara University
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