Synthesis and Biological Activity of a New Class of Sulfone-Linked Pyrrolylpyrazoles and Pyrrolylisoxazoles from Methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate
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概要
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A new class of sulfone-linked bis heterocycles, methyl-3-(4′-aryl-1′H-pyrazol-3′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (8), methyl-3-(1′-phenyl-3′,5′-diaryl-1′H-pyrazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (9) and methyl-3-(3′,5′-diarylisoxazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (10) were prepared by the regioselective reaction of methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate (2) with tosylmethyl isocyanide followed by fuctionalization of olefin moiety with 1,3-dipolar reagents. The lead compounds were tested for their antimicrobial activity.
- 公益社団法人 日本薬学会の論文
著者
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Mahesh Konda
Department of Chemistry, Sri Venkateswara University
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Padmaja Adivireddy
Department of Chemistry, Sri Venkateswara University
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Padmavathi Venkatapuram
Department Of Chemistry Sri Venkateswara University
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Radha Lakshmi
Department of Chemistry, Sri Venkateswara University
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Padmaja Adivireddy
Department Of Chemistry Sri Venkateswara University
関連論文
- Synthesis and Bioassay of Oxazolyl/Thiazolyl Selenadiazoles, Thiadiazoles and Diazaphospholes
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- Michael Adducts : Source for Biologically Potent Heterocycles
- Synthesis and Biological Activity of a New Class of Sulfone-Linked Pyrrolylpyrazoles and Pyrrolylisoxazoles from Methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate
- Synthesis and Bioassay of Amino-pyrazolone, Amino-isoxazolone and Amino-pyrimidinone Derivatives
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