Sesquiterpene Coumarins from Ferula fukanensis and Their Pro-inflammatory Cytokine Gene Expression Inhibitory Effects

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概要

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• Six new sesquiterpene coumarin derivatives, fukanefuromarin H–M (1–6), were isolated from an 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, particularly heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) gene expression in a murine macrophage-like cell line (RAW264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ).

著者

• Kitanaka Susumu

  School Of Pharmacy Nihon Univ.

• Daikonya Akihiro

  School Of Pharmacy Nihon Univ.

• Motai Tsunetake

  School of Pharmacy, Nihon University

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