Discovery of Aromatic Components with Excellent Fragrance Properties and Biological Activities: β-Ionols with Antimelanogenetic Effects and Their Asymmetric Syntheses
スポンサーリンク
概要
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Both enantiomers of dihydro-β-ionol and β-ionol, contained in the aromatic components of Osmanthus flower and of Hakuto peach, were obtained with high optical purity by lipase-catalyzed kinetic resolution of the racemates. It was found that all these enantiomers had different characteristic favorable scents and high antimelanogenetic effects. The absolute configuration and the enantiomer ratios of dihydro-β-ionol in the aromatic components of Osmanthus flower and of Hakuto peach were determined. The asymmetric synthesis of (R)-dihydro-β-ionol, one of the most valuable raw materials for fragrance and flavor, was performed from inexpensive β-ionone via lipase-catalyzed dynamic kinetic resolution followed by reduction.
著者
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Akai Shuji
School Of Pharmaceutical Sciences University Of Shizuoka
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Egi Masahiro
School Of Pharmaceutical Sciences University Of Shizuoka
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IKAWA Takashi
School of Pharmaceutical Sciences, University of Shizuoka
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Fukawa Hidemichi
Yukiguni Aguri Co., Ltd.
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Hattori Kazuyo
Kanebo Cosmetics Inc.
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Komaki Ryoichi
Kanebo Cosmetics Inc.
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Saito Kozumo
School of Pharmaceutical Sciences, University of Shizuoka
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Ishikawa Natsuyo
Kanebo Cosmetics Inc.
関連論文
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- Experimental and Theoretical Studies on Regiocontrol of Benzyne Reactions Using Silyl and Boryl Directing Groups
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