The Role of Angiotensinases in the Renin-Angiotensin System
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1. Renin contents of the kidney and angiotensinases in the plasma and kidney were studied in various species of the vertebrates. No definite correlation was observed between the activities of these two systems. Renal renin is lacking in elasmobranchs and cyclostomes, while angiotensinases exist in both classes.<BR>2. Properties of plasma and kidney angiotensinases and effects of enzyme inhibitors were compared in the rat and lamprey, a fish belonging to cyclostomes which possessed angiotensinase activities comparable to those of the rat.<BR>Angiotensinase activity of the rat plasma was the highest at nearly neutral pH at 37°C and was blocked almost completely by dialysis against ethylenediaminetetraacetic acid (EDTA). In lamprey, the optimum pH of plasma angiotensinases was between 7.9-9.0 at 20°C. It was also inhibited by EDTA.<BR>Kidney extract contained at least two different angiotensinases in either species which had pH optima at near 7.4 and 4.5-5.5. The angiotensinase active at neutral pH was inhibited by acidification and dialysis against EDTA. The latter activity was blocked markedly by diisopropyl fluorophosphate.<BR>3. Angiotensinase activity in the plasma of bilaterally nephrectomized rats was determined 24 hours after the operation. No significant change was observed after the bilateral nephrectomy.<BR>4. It is unlikely that angiotensinases were specific enzymes which involved only in inactivation of angiotensin II. They may not be concerned in the mechanism of blood pressure elevation in the hypertensive cardiovascular disease by regulating the activity of renin-angiotensin system.
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- The Role of Angiotensinases in the Renin-Angiotensin System
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