Human Growth Hormone Secretion and Stress
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Human growth hormone (HGH) secretion was studied in 33 subjects undergoing abdominal and cerebral surgery, in 6 normal adult subjects exposed to cold for the period of 1 or 2 hours and in 3 subjects whose body temperature was elevated following an injection of pyrogen CB. HGH concentration was assayed by chromatoelectrophoretic radioimmunoassay.<BR>Minor abdominal surgery under spinal anesthesia produced a moderate elevation of serum HGH with a peak at 60 minutes after the onset of the operation. Major abdominal surgery under general anesthesia with fluothane and nitrous oxide was followed by a marked increase of HGH level (42.0±15.0ng/ml) at 30 to 90 minutes after the onset of the operation, whereas serum cortisol increased on while the operation continued. The increased HGH response to surgical stress could not be suppressed by glucose infusion during the operation. In normothermic cerebral surgery (meningioma and haemangioma), HGH levels increased with peaks (16.0 and 24.0ng/ml) at 60 and 90 minutes after the operation began, whereas in hypothermic cerebral operation HGH levels did not lead to any significant changes until the body temperature commenced to recover to normal after the operation. Absence of increased HGH response to cerebral surgery under hypothermia suggests that hypothermia may suppress hypothalamic-pituitary axis in regulation of HGH secretion. However, a possibility remains that the increased HGH response to surgical stress was suppressed by premedication with chlorpromazine.<BR>In order to investigate whether HGH secretion is affected by hypothermia, 2 male and 4 female normal subjects fasted overnight were exposed to cold (4°) for the period of 1 or 2 hours. No increase of serum HGH level was found during cooling but a significant increment ranging 3.1 to 13.5ng/ml was observed on rewarming at room temperature in any cases with or without prior oral administra tion of 20 mg beta blockage (propranolol). NEFA increased to 113-267% of the initial value by 113-267% and serum cortisol showed only a slight increment ranging 2.4 to 7.9pg/100 ml during or after cold exposure.<BR>Pyrogen CB (0.1 ml per kg of body weight) was injected intravenously into one normal subject and 2 patients with growth retardation. As fever increased to 37°8'- 38°, moderate increases of HGH level (from 1.2 to 7.0ng/ml) and serum cortisol concentration (12.0 to 25.0μg/ml) were observed, but the injection into growthretarded patients who showed no HGH response to hypoglycemia, did not produce any increase of HGH level.<BR>In conclusion, HGH secretion was stimulated by surgical stress in normothermia and pyrogen injection, but not by cold stress.
- Japan Society of Clinical Chemistryの論文
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- Human Growth Hormone Secretion and Stress
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