Effect of Catecholamine on Formation of Cyclic 3', 5' -AMP in Incubated Slices of Brain
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The effect of catecholamine on formation of cyclic 3', 5' -AMP in incubated slices of brain was examined either by using the slices pre-labeled with <SUP>14</SUP>C-adenine and by measuring the conversion rate of the incorporated <SUP>14</SUP>C to <SUP>14</SUP>C-cyclic AMP or by assaying the cyclic AMP content in the incubated slices after enzymic conversion to ATP. A comparative study with 6 different mammals indicated that adenyl cyclase of human cerebral cortex is most sensitive to norepinephrine, having a characteristic of the β -adrenergic receptor. Norepinephrine, histamine and serotonin showed synergistic effects each other as to stimulation of cerebral adenyl cyclase of a guinea pig. Mem-brane depolarization elicited by high potassium ions or depolarizing agents, such as veratridine and ouabain, potentiated the effect of norepinephrine in both guinea pig and human cerebral cortex.<BR>Synergism between membrane depolarization and catecholamine suggests that catecholamine would be a secondary modifier of brain adenyl cyclase while the electrical activity would be a primary one. Significance of occurrence of norepinephrinesensitive adenyl cyclase in human brain was discussed in relevance to pathogenesis of affective psychosis.
- Japan Society of Clinical Chemistryの論文
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- Effect of Catecholamine on Formation of Cyclic 3', 5' -AMP in Incubated Slices of Brain