Studies for Relationship of Impairment of hpid Metabolism with Peroxide by Aging and for their Control by α-Tocopheml
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The contents of thiobarbituriacc id reactives ubstances (TBARs) in rat hepatic subcellularo rganellesa nd in serum increased with aging and this evidence was observed in earlierp eriod in hepatic microsomes ratherthan in serum. The TBARS leveli n hepatic microsomes from three month old rats was significantlhyi gher than that in one month old rats and its concentration in 12 month old rats reached 9 times ashigher as that in one month old rats. ln tocopherola dministrationt o rats for 12 month, the TBARS concentration in serum and in hepatic microsomes were lower than those of control rat and the tendency of increase of this concentration with aging was moderate in this group during the observation period.<BR>Synthetic activitieosf cholesterola nd fatty acid in rat liver decreased concomitantly with agirlg. However, those activitiedsi d notdecrease significantliyn the rats fedtocopherol for long period. Elevation of serum lipid concentration with aging was moderate in tocopherol administeredr ats for 6 to 12 months and was significantlyo wer as compared with that in control rats. ln addition, the phospholipid content in liver was higher and triglyceridceo ntent was lower after long term feeding of tocopheroL<BR>TBARS content in serum and hepatic subcellularo rganelleso f rats fed tocopherol free diet increased markedly and lower syntheticactivitieosf hepatic cholesterola nd fatty acid as well as glucose-6-phosphatase in microsomes were observed after two weeks. Refeedirlg of tocopherolrichd iet to the rats decreased the TBARS Ievels andrepaired the synthetic activitietso normal. ln tocopherol deficientr ats, supplementof 2% cholesterolt o tocopherol deficientd iet increased merkedly theserum cholesteroland phospholipid.<BR>From these results above mentioned, it is considered that the TBARS production in hepatic microsome is prevented by tocopherol administrationvery, efficient8ywhiclhe ad to the prevention of the impairment of the function of hepatic subcellular organelles concomitantly with aging.
- Japan Society of Clinical Chemistryの論文
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