Uric Acid Metabolism in Long Distance Male and Female Runners

概要

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Subjects in this study included long distance runner ( 6 men and 10 women) selected from members of a track and field club. Urine was collected two hours after the lasting voiding (immediatery after an early morning trainig session of 5 to 10km or before noon on days without training)to compare the dynamics of uric acid, hypoxanthine, and xanthine. The results are listed below:<BR>1) The serum uric acid level among young adult long distance runners was significancy higher in men than in women. A relatively low uric acid and creatinine clearance ratio in men compared to that of women is thought to explain this difference.<BR>2) It was suggested that exertion imposed by long distance running caused an increase in uric acid production; but no increased in the serum uric acid level was recognized in women with high uric acid clearance rates. A significant rise in the serum uric acid level was noted among men after long distance running but none developed hyperuricemic symptoms when the serum uric acid level exceeded 7.0mg/100ml.<BR>3) Fluctuations in the levels hypoxanthine and xanthine, two precursors of uric acid, induced by long distance running were generally similar to the changing patterns of the uric acid level. It was suggested that long distance running dose not induced continued hyperuricemia.