Influence of Concomitant Hypertension on the Occurrence of Microalbuminuria in Patients with Gout.

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The presence of renal dysfunction is one of the most critical factors for the long-term outcome of patients with gout. It has been debated whether the renal dysfunction in these patients results from hyperuricemia itself or from the complication of hypertension or atherosclerotic diseases. We measured daily excretion of albumin in urine in 218 patients with gout or hyperuricemia with a sensitive radioimmunoassay system. Microalbuminuria, defined as albumin excretion into urine at the rate of 20μg/min to 200μg/min, was detected in 14.7% of gouty subjects. Urinary excretion of albumin had no relationship to serum β<SUB>2</SUB>-microglobulin, urinary β<SUB>2</SUB>-microglobulin, NAG, or urine volume. A significant increase in the incidence of microalbuminuria after the onset of the first gouty arthritis was observed in patients with concomitant hypertension but not in those without hypertension. These results suggest that the concomitant hypertension is involoed in the glomerular lesion in patients with gout.
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