THE CLINICOPATHOLOGICAL STUDY OF PEPSINOGEN METHOD-NEGATIVE AND Helicobacter pylori-POSITIVE GASTRIC CANCER

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We compared the clinicopathological characteristics of pepsinogen (PG) method-negative and Helicobacter pylori (HP)-positive gastric cancer (PG(-) HP(+)group) by tissue type to a PG(+) group. The result was that, of 226 cases of gastric cancer, the PG(-) HP(+) group accounted for 29.6% and the PG(+) group accounted for 63.3%. Cancer was frequently the undifferentiated type in the PG(-) HP(+) group and the differentiated type in the PG(+) group; early-stage cancer was frequently found in the PG(-) HP(+) group, although there were no significant differences. The PG(-) HP(+) group was younger than the PG(+) group, and the undifferentiated type tended to be found frequently in women. With regard to site, the differentiated type in the PG(+) group tended to be found frequently in the L region and in the M region in the PG(-) HP(+) group. The proportion of differentiated M cancer of less than 2cm suited to EMR was 21.7% for the PG(+) group. In contrast, it was higher at 29.9% for the PG(-) HP(+) group and, compared to the PG(+) group, cancer predominated in the M region, most were the depressed type, and there was a high rate of tub2 cases. This cancer is surmised to be one having a character close to that of an undifferentiated type. Thus, early detection of gastric cancer in the PG(-) HP (+) group is considered to be significant. To that end, individuals at risk for gastric cancer must be narrowed down considering use of PG measurements as well and they must be induced to undergo an endoscopic exam.

THE CLINICOPATHOLOGICAL STUDY OF PEPSINOGEN METHOD-NEGATIVE AND <I>Helicobacter pylori</I>-POSITIVE GASTRIC CANCER

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