Measurement of Hemoglobin A<SUB>1</SUB> (A<SUB>1</SUB>C) and its Clinical Implications
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概要
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Three aspects were under consideration through daily experiences.<BR>Regarding to unstable HbA<SUB>1</SUB> in microcolumn chromatography, further improvements in accuracy and specificity should be rather required, otherwise at least in present method, there were no significances in removing unstable HbA<SUB>1</SUB> by pretreatment of erythrocytes.<BR>In the cases of HbA<SUB>1</SUB> elevation aside from diabetes mellitus, determinations of HbA<SUB>1</SUB> subcomponents were desirable and subsidiary index of HbA<SUB>1a+b</SUB>/HbA<SUB>1c</SUB> ratio was available.<BR>From long-term follow-up study, it was demonstrated that HbA<SUB>1c</SUB> has proved to be more useful than FBS in assessing the degree of patient control, especially under insulin therapy.
- Japan Society of Clinical Chemistryの論文
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