The New Hydrogen Peroxide Electrode for the Glucose Analyzer

概要

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The automatic glucose analyzer with new hydrogen peroxide electrode produced by Mitsubishi Chemical Industries, LTD. is described. The automatic glucose analyzer consists of new hydrogen peroxide electrodes, ionexchange column and immobilized glucose oxidase silicagel column. The merit of this electrode is that the electrode can measure hydrogen peroxide generated from glucose under laminar flow without electrode membrane or inclusion electrolytes. The tested results of this analyzer for response to variables in clinical use are as followings; 1) Standard curve for glucose concentrations shows linear correlation to electrical current in O to 700 mg/dl of concentration. 2) This electrode reacts slightly to bilirubin, but it has no influence to glucose measurement clinically. 3) This electrode, however, reacts directly to glutathione, EDTA, ascorbic acid andhemoglobin. The most of these substances are removed easily by using ion-exchange resin except ascorbic acid. As these experiments are carried out under abnormal concentration of these substances, influences of them to glucose value are negligible clinically. 4) Measured values of glucose by this analyzer and other procedures reveal a good correlation between them. It should be considered that the automatic glucose analyzer with new hydrogen peroxide electrodes is useful to measure glucose in biological materials.
Japan Society of Clinical Chemistryの論文