Studies on Hyperlipidemia in Multiple Myeloma:Interaction between Serum Ig-A and LDL-Fraction of a Patient Bearing Ig-A, Lambda Type Multiple Myeloma with Hyperlipidemia

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Investigations on lipide metabolism have been performed on a seventy years old woman bearing Ig-A, lambda type multiple myeloma with hyperlipidemia of type II-b or type III classified according to Fredrickson. She showed increased serum, levels of cholesterol, cholesterol-ester, triglyceride and phospholipide, and she was accompanied with retention of vitamin-A by vitamin- A tolerance test, delayed FFA release by PHLA test and increased LCAT. The serum of the patient was divided into several fractions by differential ultracentrifugation. The bottom-fraction (d>1.21) made precipitate with the LDL-fraction by ouchterlony's double diffusion technique and also precipitated with other LDL-fractions obtained from a healthy control or a multiple myeloma without hyperlipidemia. In the mixture of patient's bottom- and LDL-fraction some new larger complexes, which were not observed in each fraction, were found by polyacrylamide gradient-gel electorphoresis. The bottom-fraction made precipitin arcs against LDL-fraction and anti Ig-kantiserum by immunoelectrophoresis, and the location of the bottom-LDL precipitate coincided with that of bottom-anti-Ig-A. These results suggest that the Ig-A of the patient serum has some affinity for LDL-fraction making complexes to interfere with lipide metabolism.
Japan Society of Clinical Chemistryの論文