The Longterm Allopurinol Treatment of Hyperuricemia accompanied with Urolithiasis

概要

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Seventeen patients with hyperuricemia accompanied with urolithiasis (8 with gout,9 without gout) were treated favorably with longterm administration of allopurinol for about 5 years to 10 years.<BR>No urolithiasis recurred throughout the therapeutic period.<BR>Of 17 patients,14 were hyperuricosuric and 3 normouricosuric.<BR>All patients were, however, normocalcemic. Calculus was recovered from 13 patients, which was according to the infrared spectra chiefly composed of calcium oxalate or phosphate in 9 patients (about 69 per cent). This means that allopurinol should be effective in the treatment of hyperuricosuric calcium urolithiasis. Depend on chemical composition of our cases, urinary tract stones accompanied with hyperuricemic patients were not always uric acid.<BR>It is recommended to analyze the underlying stone as far as possible for controlling the urinary pH value correspondingly to the nature of the stone.
Japanese Society of Gout and Nucleic Acid Metabolismの論文