Acid Soluble Proteins(ASP)in Sera from Patients with Primary Gout

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Acute arthritis of gout frequentry associates with the elevation of erythrocyte sedimentation rate (ESR) and acute phase reactant; including c-reactive protein (CRP), α1-acid glycoprotein, α1-antitrypsin, seromucoid, α1-macroglobulin and α2-macroglobulin. Recently, among the acute phase reactants acid soluble proteins (ASP), which are solublized in 6M perchloric acid solution, are utilized widely as a routine laboratory examination.<BR>In this study we evaluated the serum levels of A SP in 88 samples gathered from 54 patients with primary gout. Serum levels of ASP from gouty patients were higher than those of normal individuals. More prominent elevation of serum ASP was observed at the time of acute gouty attacks. When serially assayed, changes of the serum level of ASP well correlated with the times of acute gouty attacks. Some patients with gouty attacks showed only the elevation of serum ASP without elevation of ESR and CRP. Serum levels of ASP did not correlate with levels of ESR and CRP at the time of acute gouty attacks.<BR>From these findings we concluded that serum levels of ASP were a useful index for acute gouty attacks.