Risk of Major Osteoporotic Fracture After Cardiovascular Disease: A Population-Based Cohort Study in Taiwan
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概要
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Background: We investigated the association between cardiovascular disease (CVD) and the risk of major osteoporotic fracture in Taiwan.<BR>Methods: Using the Taiwan National Health Insurance Database for the period 2000–2007, we classified 43 874 patients aged 50 years or older with newly diagnosed CVD (coronary artery disease, heart failure, cerebrovascular disease, or peripheral atherosclerosis) as the CVD group and 43 874 subjects without CVD (frequency-matched by sex, age, and date selected) as the non-CVD group. Incidence and hazard ratios (HRs) for major osteoporotic fracture of the spine, hip, humerus, and forearm/wrist were estimated for the period until the end of 2010.<BR>Results: After adjustment for confounders, the overall HRs for major osteoporotic fracture were 1.24 (95% CI = 1.13, 1.36) in men with CVD and 1.18 (95% CI = 1.11, 1.25) in women with CVD, as compared with the non-CVD group. As compared with the non-CVD group, the adjusted HR for major osteoporotic fracture was highest among subjects with cerebrovascular disease (HR 1.31; 95% CI 1.23, 1.39), followed by those with heart failure (HR 1.18; 95% CI 1.11, 1.27), peripheral atherosclerosis (HR 1.12; 95% CI 1.04, 1.20), and coronary artery disease (HR 1.07; 95% CI 1.01, 1.12).<BR>Conclusions: CVD is associated with risk of major osteoporotic fracture in men and women in Taiwan.
著者
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Sung Fung-chang
Department Of Public Health And Institute Of Environmental Health China Medical University And Hospi
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Lai Shih-wei
School Of Medicine China Medical University
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LAI Shih-Wei
School of Medicine, China Medical University
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Lin Cheng-li
Department of Electronic Engineering, Feng Chia University, Taichung, Taiwan 407, Republic of China
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Lai Hsueh-Chou
School of Chinese Medicine, China Medical University
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Liao Kuan-Fu
Graduate Institute of Integrated Medicine, China Medical University
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Tsai Pang-Yao
Department of Public Health, China Medical University
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Chen Pei-Chun
Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
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