Cytotoxic and Anti-angiogenic Properties of Minor 3,4-seco-Cycloartanes from Gardenia sootepensis Exudate
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概要
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Gardenia plants have long been used as traditional medicines in various countries including Thailand. In this study, two new 3,4-seco-cycloartane triterpenes, sootependial (1) and sootepenoic acid (2), were isolated from bud exudate of G. sootepensis, together with five known compounds. Their structures were elucidated on the basis of spectroscopic data. Sootependial (1) showed potent cytotoxicity selective to Hep-G2 cell lines and anti-angiogenic activity in ex vivo model (a rat aortic ring sprouting) assay. Furthermore, its angiogenic effect was found to occur mainly by suppressing endothelial cell proliferation and tubule formation, suggesting the potential of 1 as a lead compound for cancer treatment.
著者
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Pudhom Khanitha
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Matsubara Kiminori
Department Of Human Life Science Education Graduate School Of Education Hiroshima University
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Pudhom Khanitha
Department of Chemistry, Faculty of Science, Chulalongkorn University
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Nuanyai Thanesuan
Department of Chemistry, Faculty of Science, Chulalongkorn University
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