Relationship between Exercise-induced QRS Axis Shift and Multiple Risk Factors for Coronary Heart Disease

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Background Though the usefulness of exercise-induced QRS axis shifts (ΔQRS) for detecting coronary artery stenosis has been reported, the relationships between ΔQRS and risk factors for coronary heart disease (CHD) remain unclear.Methods Consecutive asymptomatic subjects (n=496), who had undergone a double Masters 2-step electrocardiographic test to screen for heart diseases in a health check-up, were enrolled in this cross-sectional observational study. We divided them into a positive ΔQRS group (>10°) and a negative ΔQRS group (≤10°) and analyzed data with reference to risk factors for CHD in the 2 groups.Results Significant differences were found between the magnitude of ΔQRS and the following multiple risk factors for CHD: age, systolic BP, diastolic BP, pulse pressure, TG, HDL cholesterol, hemoglobin A1c, BMI, waist circumference, metabolic syndrome, and Framingham risk score.Conclusion The magnitude of ΔQRS may be useful in a noninvasive assessment of the extent of coronary atherosclerosis in asymptomatic individuals.