Electrical Remodeling in Persistent Atrial Fibrillation May Be Mediated by Changes in the IKATP Channel
スポンサーリンク
概要
- 論文の詳細を見る
The goal of this study was to measure the effective refractory period (ERP), the conduction velocity (CV) and the wavelength (WL) after cardioversion in patients with persistent atrial fibrillation (AF) and to determine the effects of the adenosine triphosphate sensitive potassium channel (K<SUB>ATP</SUB>) opening agent, nicorandil, on those parameters in patients with persistent AF.<BR>METHODS: Patients with AF underwent elective cardioversion followed by measurement of ERP and CV before and after administration of nicorandil. Parameters were measured again one week later, and the ERP and the CV was used to calculate WL.<BR>RESULTS: ERP was significantly shorter immediately after termination of AF than at the 1-week time point (193.4 vs. 228.7 msec <I>p</I><0.01). While there was no significant difference in ERP immediately after termination of AF when comparing measurements taken before and after the administration of nicorandil, ERP at the 1-week time point was shorter after nicorandil administration than before nicorandil administration (193.4 vs. 191.4 msec, n.s.; 228.7 vs. 217.2 msec, <I>p</I><0.01). Further, WL was higher at the 1-week time point after nicorandil administration than before nicorandil administration.<BR>CONCLUSIONS: These data indicate that the electrical remodeling that occurs after cardioversion is at least partially mediated by changes in K<SUB>ATP</SUB> channel behavior. Further, the electrophysiologic properties, that is, nicorandil prolonging the WL, may be of benefit in reducing the recurrence rate of AF.
- 日本不整脈学会の論文
著者
-
Katagiri Takashi
The Third Department of Internal Medicine, Showa University school of Medicine
-
Tanno Kaoru
the third department of internral medicine, showa university scholl of medicine
-
asano taku
the third department of internral medicine, showa university scholl of medicine
-
Miyoshi Fumito
The Third Department of Internal Medicine, Showa University School of Medicine
-
Minoura Yoshino
The Third Department Of Internal Medicine Showa University School Of Medicine
-
Matsuyama Takaaki
The Third Department of Internal Medicine, Showa University School of Medicine
-
Watanabe Norikazu
The Third Department of Internal Medicine, Showa University School of Medicine
-
Kobayashi Youichi
The Third Department Of Internal Medicine School Of Medicine Showa University
-
Miyata Akira
The Third Department of Internal Medicine, Showa University School of Medicine
-
Katagiri Takashi
The Third Department Of Internal Medicine Showa University
-
Kawamura Mitsuharu
The Third Department of Internal Medicine, Showa University School of Medicine
-
Liu Chungchang
The Third Department of Internal Medicine, Showa University School of Medicine
-
Tanno Kaoru
The Third Department of Internal Medicine, Showa University School of Medicine
-
Asano Taku
The Third Department of Internal Medicine, Showa University School of Medicine
関連論文
- OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
- OE-260 Impact of Cardiac Rehabilitation on 10-year Mortality in Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-256 Effects of Cardiac Rehabilitation are Pronounced in Elderly Patients with Acute Myocardial Infarction(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis
- High-Dose Granulocyte-Colony Stimulating Factor Promotes Neointimal Hyperplasia in the Early Phase and Inhibits Neointimal Hyperplasia in the Late Phase After Vascular Injury
- PJ-901 Strong Correlation between Small LDL-Cholesterol and Negative Net Charge Fraction of LDL in Patients with and without Coronary Artery Disease(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
- PJ-233 Elevated Small Dense Low-density Lipoprotein Cholesterol to Risk Marker for Stable Coronary Heart Disease, Independent of Adiponectin and C-reactive protein(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeti
- PJ-167 Remarkably High Levels of Small LDL-cholesterol in Younger Patients with Acute Coronary Syndrome and Metabolic Syndrome(Preventive medicine/Epidemiology/Education(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
- PE-502 Not LDL-Cholesterol But Apolipoprotein A1 is an Important Risk Marker for Severe Coronary Atherosclerosis in Patients Treated with Lipid-lowering Drugs(Atherosclerosis, clinical(08)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of
- PE-150 Acceleration of vascular repair after injury in adiponectin-overexpressing mice.(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 2 High Levels of Small Dense LDL-cholesterol as Atherogenic and Metabolic LDL in Patients with Acute Coronary Syndrome(Symposium 3 (SY-03) (IHD) Metabolic Syndrome and Atherosclerosis,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-285 Histological Features Around the Three Aortic Cusp Regions, Implication for the Radiofrequency Catheter Ablation for Atrial and Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-14, The 71st Annual Scientific Meeting of the Japanese
- OE-410 Long-term Effects of Dietary-lifestyle Modification at 6 months after Hospital Discharge in Patients with Acute Myocardial Infarction(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Ja
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- PJ-901 Strong Correlation between Small LDL-Cholesterol and Negative Net Charge Fraction of LDL in Patients with and without Coronary Artery Disease(Lipid disorders(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
- PJ-233 Elevated Small Dense Low-density Lipoprotein Cholesterol to Risk Marker for Stable Coronary Heart Disease, Independent of Adiponectin and C-reactive protein(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeti
- PJ-167 Remarkably High Levels of Small LDL-cholesterol in Younger Patients with Acute Coronary Syndrome and Metabolic Syndrome(Preventive medicine/Epidemiology/Education(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
- PE-502 Not LDL-Cholesterol But Apolipoprotein A1 is an Important Risk Marker for Severe Coronary Atherosclerosis in Patients Treated with Lipid-lowering Drugs(Atherosclerosis, clinical(08)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of
- 2 High Levels of Small Dense LDL-cholesterol as Atherogenic and Metabolic LDL in Patients with Acute Coronary Syndrome(Symposium 3 (SY-03) (IHD) Metabolic Syndrome and Atherosclerosis,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-285 Histological Features Around the Three Aortic Cusp Regions, Implication for the Radiofrequency Catheter Ablation for Atrial and Ventricular Tachycardia(Arrhythmia, diagnosis/pathophysiology/EPS-14, The 71st Annual Scientific Meeting of the Japanese
- PJ-098 Left Ventricular Torsion Measured by Speckle Tracking Imaging will be New Quantitative Approach for Assessment of Systolic Function(Echo/Doppler-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-073 Mechanism of Neurally Mediated Syncope(Autonomic nervous system-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Production of hydrogen peroxide in situ in cardiac myocytes during hypoxia-reoxygenation as assessed with cerium
- Bone Marrow Cells Differentiate into Neointimal Smooth Muscle Cells at the Injured Artery
- Accumulation of Hematopoletic Cells Prior to Smooth Muscle Cells Hyperplasia
- PJ-279 Effect of Patients with Atrioventricular Block Undergoing Right Septal Ventricular Lead Implantation Compared with Right Apical Pacing(PJ047,Arrhythmia, Others (Clinical/Pathophysiology) 3 (A),Poster Session (Japanese),The 73rd Annual Scientific Me
- PJ-399 Effect of Candesartan and Interleukin-6 and Type 3 Procollagen Peptide Reduction on Maintenance of Sinus Rhythm for Atrial Fibrillation(Arrhythmia, therapy(20)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulati
- FRS-099 Characterristics of Lesions Created with Cooled-tip Epicardium Ablation in Pigs : Comparison of Close to and Further from Coronary Arteries(Clinical Arrhythmia-3 (A) FRS20,Featured Research Session (English),The 70th Anniversary Annual Scientific
- PJ-382 Effect of Smoking on Postprandial Changes of Whole Blood Rheology and Coronary Flow Velocity Reserve in Healthy Men(Echo/Doppler-11 (I) PJ65,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
- Postprandial Changes in LDL Phenotypes in Patients with Myocardial Infarction(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Close Linkage Between Hypoadiponectinemia and Small Dense LDL as a Potent Risk Factor for Coronary Heart Diseases(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Significance of Small Dense Low-Density Lipoprotein-Cholesterol Concentrations as Angiographic and Clinical Severity of Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- STUDIES ON ULTRASTRUCTURE AND CYTOCHEMICAL ATPase ACTIVITY IN HUMAN CARDIAC MYOCYTES FROM BIOPSIES FROM PATIENTS WITH VARIOUS HEART DISEASES
- ELECTRON MICROSCOPIC STUDIES ON THE ATPase ACTIVITY IN MYOCARDIAL INFARCTION: Changes in the Early Myocardial Infarction
- -141-STUDIES ON THE CARDIAC SARCOPLASMIC RETICULUM (SR) IN MYOCARDIAL INFARCTION : Cardiac Metabolism : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- COMPARISON OF HEMODYNAMICS IN PATIENTS WITH MYOCARDIAL INFARCTION FOR STRESS WITH BATHING AND WITH EXERCISE
- COMPARISON OF HEMODYNAMICS IN PATIENTS WITH MYOCARDIAL INFARCTION FOR STRESS WITH BATHING AND WITH EXERCISE
- -0054-CHANGE OF ATRIAL NATRIURETIC PEPTIDE (α-hANP) ON BATHING IN PATIENTS WITH MYOCARDIAL INFARCTION : CHIEFLY IN COMPARISON WITH HEMODYNAMICS BY INVASIVE METHODS
- EFFECTS OF WARM BATH DEPTH ON HEMODYNAMICS IN PATIENTS WITH MYOCARDIAL INFARCTION : Exercise Test, Rehabilitation : 53 Annual Scientific Meeting, Japanese Circulation Society
- -0722- BENEFICIAL EFFECT OF PREINFERCTION ANGINA PECTORIS ON LEFT VENTRICULAR FUNCTION AFTER ACUTE MYOCARDIAL INFARCTION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Comparisons Between Hemodynamics, During and After Bathing, and Prognosis in Patients With Myocardial Infarction
- P100 Changes of cerebral blood Bow and hemodynamics in different pacing rate : Using transcranial color doppler imaging
- 0297 Dobutamine stress echocardiography for assessment of myocardial viability and residual ischemia in first acute myocardial infarction
- -P203- ASSESSMENT OF VIABILITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION : STUDY OF UTILITY ON LOW-DOSE DOBUTAMIN STRESS ECHOCARDIOGRAPHY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECTS OF WARM BATH DEPTH ON HEMODYNAMICS IN PATIENTS WITH MYOCARDIAL INFARCTION.COMPARISON OF HEMODYMAMIC CHANGES BETWEEN SITTING AND SUPINE POSITION
- Selective Slow Pathway Ablation in Atrioventricular Nodal Reentrant Tachycardia : Comparison of Different Methods and the Site of Slow Pathway Ablation
- Dipyridamole Suppresses Catecholamine- and Ca^ Influx-Sensitive Ventricular Arrhythmias
- HISTOPATHOLOGY OF CANINE HEARTS SUBJECTED TO CATHETER ABLATION USING RADIOFREQUENCY ENERGY
- DUAL ATRIOVENTRICULAR NODAL PATHWAYS IN PATIENTS WITH WOLFFPARLKINSON-WHITE SYNDROME UNDERGOING CATHETER ABLATION
- Transmural Dispersion of Repolarization (TDR) Important Predictor to Occur Ventricular Tachyarrhythmias (VT)
- Differences in the Association of LDL phenotypes with Postprandial Hypertriglyceridemia in Men With and Without Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 0551 HISTOCHEMICAL DEMOSTRATION OF HYDROGEN PEROXIDE GENERATION IN ENDOTHELIAL CELLS AND MITOCHONDRIA IN RAT HEARTS
- -0308- ENDOGENOUS CATALASE FILLS THE ROLE OF A CO-FACTOR WITH SUPEROXIDE DISMUTASE AS A DEFENSE MECHANISM AGAINST REPERFUSION INJURY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- PJ-059 RAS Inhibitor Prevent Atrial Fibrillation after PV Isolation(Arrhythmia, therapy-15, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-185 Usefulness of Candesartan and Bepridil to Maintain of Sinus Rhythm in Patients with Atrial Fibrillation(Arrhythmia, therapy-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-017 Non-Sustained Ventricular Tachycardia in Patients with Organic Heart Disease(Arrhythmia, Diagnosis/Pathophysiology/EPS 1 (A) : PE3)(Poster Session (English))
- OE-099 The electrophysiological responses of sympathetic preganglionic neurons to angiotensin II(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-333 Evaluation of antiarrhythmic agents for ventricular tachyarrhythmias using microvolt T wave alternans(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
- Microvolt T Wave Alternans Is Associated with Left Ventricular Remodeling after Myocardial Infarction
- Microvolt T Wave Alternans of Patients with Coronary Artery Disease and Sustained Ventricular Tachyarrhythmia
- Atrial Fibrillation Recurs in Patients with Decreased Conduction Velocity and Large Heterogeneity of Effective Refractory Period after Electrical Defibrillation
- Reduced Ejection Fraction Is not Good Enough to Indicate ICD for Japanese Patients with Prior Myocardial Infarction
- Comparison of Electrophysiologic Study with Microvolt T Wave Alternans to Predict Recurrence of VT in Patients with Organic Heart Disease
- Utility of cooled tip catheter and intracardiac echocardiography for ventricular tachycardia originating from left ventricular outflow tract
- OJ-122 Comparison between ATP and Isoproterenol Tilt Testing in Patients with Unexplained Syncope(ECG/Body surface potential mapping/Holter-2 (A) OJ21,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- Mitochondrial Respiratory Impairment in Streptozotocin-Induced Diabetic Rat Heart
- PATHOLOGICAL STUDY OF CHRONIC ATRIOVENTRICULAR BLOCK : COMPARATIVE STUDY WITH HIS BUNDLE ELECTROCARDIOGRAM
- Generation of Free Radicals and the Damage Done to the Sarcoplasmic Reticulum During Reperfusion Injury Following Brief Ischemia in the Canine Heart
- STUDIES ON INTRACARDIAC ACID HYDROLASES IN THE ISCHEMIC MYOCARDIAL NECROSIS
- Different characteristics of T wave alternans between polymorphic VT and monomorphic VT
- ALTERATION OF SARCOLEMMAL PERMEABILITY DUE TO ISCHEMIA AND REPERFUSION BY USE OF ELECTRON MICROSCOPY
- -425- EFFECTS OF ISOPROTERENOL ON ULTRASTRUCTURAL DISTRIBUTION OF ATRIAL GRANULES : AN IMMUNOELECTRON MICROSCOPIC STUDY
- Antioxidant N-Acetylcysteine Inhibits Vasoactive Agents-Potentiated Mitogenic Effects of Mildly Oxidized LDL on Vascular Smooth Muscle Cells
- Role of Plasma Catecholamines and Arginine Vasopressin in Neurally Mediated Syncope during Head-up Tilt Testing(Autonomic Nervous System 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Quantification of Dyssynchrony and Mechanism of Increment of Cardiac Systolic Function after Biventricular Pacing Therapy Elucidated by Tissue Doppler Imaging
- Effects of Aging on Responses to Head-Up Tilt Testing with or without Isoproterenol in Patients with Unexplained Syncope
- Hormonal Responses to Disopyramide Administration in Neurally Mediated Syncope during Head-up Tilt Testing
- -0658-RADIOFREQUENCY CATHETER ABLATION IN THE CORONARY SINUS
- PJ-406 Quantitative Assessment of Left Atrial Diastolic and Systolic Function (difference of sites) Using by Tissue Strain Imaging in Normal Subjects.(Cardiac Function, Basic/Clinical 2 (M) : PJ68)(Poster Session (Japanese))
- PJ-059 Nocturnal Oxygen Therapy Prevents Progress of Congestive Heart Failure with Central Sleep Apnea(Heart failure, clinical-18 (M) PJ10,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Effects of Pharmacological Therapy for Vasovagal Syncope on the Basis of Reproducibility During Head-Up Tilt Testing
- The medical therapy of cardioinhibitory malignant vasovagal syncope during head-up tilt testing
- EFFECTS OF ATRIAL PACING ON THE ULTRASTRUCTURAL LOCALIZATION OF ATRIAL GRANULES AND THE SERUM CONCENTRATION OF ATRIAL NATRIURETIC POLYPEPTIDE : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULA
- STUDIES ON COLLAGEN IN THE EZPERIMENTAL MYOCARDIAL INFARCTION MYOCARDIAL INFARCTION
- DEGRADATION OF CARDIAC SARCOPLASMIC RETICULUM IN ACUTE MYOCARDIAL ISCHEMIA : Cardiac Metabolism (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- CHANGES IN CARDIAC SARCOPLASMIC RETICULUM IN THE ISCHEMIC MYOCARDIUM : A FREEZE-FRACTURE STUDY : Pathology, Morphology : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- ULTRASTRUCTURAL HISTOCHEMICAL STUDIES ON ATPase ACTIVITY IN BIOPSIED HUMAN MYOCARDIAL CELLS IN VARIOUS HEART DISEASES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Pathology Morphology
- COMPARATIVE STUDIES ON MORPHOMETRIC AND BIOCHEMICAL ANALYSIS OF MYOFIBRILS IN PATIENTS WITH CARDIOMYOPATHIES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiomyopathy
- ASSESSMENT OF PROTECTION OF ISCHEMIC MYOCARDIAL INJURY WITH BIOCHEMICAL AND ULTRASTRUCTURAL STUDIES IN CORONARY REPERFUSION MODEL EXPERIMENT : WITH EMPHASIS ON METHODOLOGY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOC
- STUDIES ON CARDIAC STRUCTURAL PROTEINS IN CARDIAC BIOPSY SPECIMENS FROM PATIENTS WITH VARIOUS HEART DISEASES : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- STUDIES ON THE BIOSYNTHESIS OF COLLAGEN IN THE RECOVERY PHASE OF MYOCARDIAL INFARCTION : Ichemic Heart Disease (III) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Usefulness of microvolt T wave alternans as a predictor of ventricular tachyarrhythmias : A prospective study using atrial pacing
- Ventricular Arrhythmias With Left Bundle Branch Block Pattern and Inferior Axis : Assessment of Their Mechanisms on the Basis of Response to ATP, Nicorandil and Verapamil
- STUDIES ON THE Na^+-K^+-ATPase IN MYOCARDIAL INFARCTION
- CHANGES IN INTRACARDIAC ACID HYDROLASES IN MYOCARDIAL INFARCTION : Myocardial Infarction : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PE-599 Insulin Resistance as a Predictor for Restenosis after Coronary Stenting(Metabolism/Biochemistry/Energetics-2 (M) PE105,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- -P288- LYMPHOCYTIC INFILTRATION IN THE BIOPSIED MYOCARDIUM AND LV WALL MOTION ABNORMALITY IN PATIENTS WITH DILATED CARDIOMYOPATHIES
- Oxidized Low-Density Lipoproteins Potentiate the Mitogenic Effect of 5-Hydroxytryptamine on Vascular Smooth Muscle Cells
- Electrical Remodeling in Persistent Atrial Fibrillation May Be Mediated by Changes in the IKATP Channel