Relations between Glomerular Filtration Rate of Chronic Kidney Disease with Cardiac Size and Function in Patients with Chronic Atrial Fibrillation

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Purpose: Decreased estimated glomerular filtration rate (eGFR) and atrial fibrillation (AF) share risk factors on cardiovascular event, and renal dysfunction is thought to be associated with the new-onset of AF. However, there had been few studies about relations between eGFR and chronic AF. Methods: Of 218 consecutive subjects with episode of AF, 67 chronic AF patients with chronic kidney disease (CKD) defined as decreased eGFR (<60 ml/min per 1.73 m−2) and were evaluated. These were divided into following three groups according to degree of eGFR: Gr-1) 45 to 60 ml/min per 1.73 m−2, Gr-2) 30 to 45 ml/min per 1.73 m−2, Gr-3)<30 ml/min per 1.73 m−2. Baseline demographic, clinical and echocardiographic characteristics were analyzed. Results: There was no difference in the presence of structural heart disease, left ventricular (LV) function and left atrial diameter by echocardiography, use of oral medications and heart failure hospitalization among the 3 groups. However, male gender (100 vs 79 vs 56 [%], respectively, P<0.001) and hemoglobin level (13.1±2.1 vs 12.3±1.8 vs 10.9±2.6 [g/dl], respectively, P<0.05) were higher in Gr 1) than Gr 2) or Gr 3). During 4±2 year follow-up, no significant change of LV function could be found between baseline and follow-up in all groups. Kaplan-Meier curves revealed that the cumulative survival rate was not difference among groups (96 vs 83 vs 88 [%], log rank test; P=NS). Conclusions: Sole kidney dysfunction had no influence to cardiac size, function and the survival of chronic AF patients.

Relations between Glomerular Filtration Rate of Chronic Kidney Disease with Cardiac Size and Function in Patients with Chronic Atrial Fibrillation

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