The Effect of Renin-Angiotensin-System-Inhibitor (RASI) on the Recurrence of Atrial Fibrillation (AF) after Pulmonary Vein Isolation (PVI) in Patients with Normal Left Atrium (LA)
スポンサーリンク
概要
- 論文の詳細を見る
<B>Background:</B> Although many experimental data support the suppressive effect of RASIs on the occurrence of AF, recent clinical trials revealed no benefit of RASIs to prevent AF. However, if appropriate patients were selected, RASIs could work more effectively. In this study, we hypothesized that RASIs was effective in patients with normal LA. <B>Methods:</B> We retrospectively studied 178 consecutive patients (mean age=60±12 yrs, 76% males) with normal LA (LA<40 mm) who underwent successful PVI for AF. Multivariate analysis was performed to clarify the predictors of AF recurrence. The effect of RASI on AF recurrence was also assessed. <B>Results:</B> AF recurred in 40 patients (22.6%) during the follow-up period (mean 498±377 days). Multivariate Cox proportional analysis revealed that treatment with RASIs (HR 0.32, 95%CI 0.14–0.71, P=0.005), duration of AF (HR 1.08/year, 95%CI 1.00–1.15, P=0.04), history of hypertension (HR 3.05, 95%CI 1.29–7.24, P=0.01), and ejection fraction (HR 0.54/10%, 95%CI 0.34–0.87, P=0.01) were associated with AF recurrence in patients with normal LA. <B>Conclusion:</B> Several factors could be the predictors of AF recurrence. RASIs could suppress AF recurrence in patients with normal LA after PVI.
- 日本不整脈学会の論文
著者
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Hirai Makoto
Department Of Circulation And Respiration Research Institute Of Environmental Medicine Nagoya Univer
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Takigawa Masateru
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Nanasato Mamoru
Cardiovascular Center Nagoya Daini Red Cross Hospital
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Hirayama Haruo
Cardiovascular Center Nagoya Dai-ni Red Cross Hospital
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Yoshida Yukihiko
Cardiovascular Center Nagoya Daini Red Cross Hospital
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Tatematsu Yasushi
Cardiovascular Center Nagoya Daini Red Cross Hospital
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Yoshida Ruka
Cardiovascular Center Nagoya Daini Red Cross Hospital
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Tatematsu Yasushi
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Yoshida Ruka
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Ando Monami
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Sairaku Akinori
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Kamiya Hiroki
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Takigawa Masateru
Cardiovascular Center, Yokosuka Kyosai Hospital
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Hirayama Haruo
Cardiovascular Center, Nagoya Daini Red Cross Hospital
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Takigawa Masateru
Cardiovascular Center, Department of Internal Medicine, Japanese Red Cross Society, Nagoya Daini Hospital
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Hirai Makoto
Department of Cardiology, Nagoya University Graduate School of Health Science
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