Long-Term Predictors of Mortality and Malignant Ventricular Arrhythmias in Patients with Right Ventricular Outflow Tract Tachycardia
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概要
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<B>Background:</B> Right ventricular outflow tract tachycardia (RVOT-T) could be the concealed form of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, the outcome of RVOT-T is variable, and the predictors of mortality and malignant ventricular arrhythmia are undefined. The purpose of this study was to investigate the predictors of long-term outcome in patients with RVOT-T. <B>Methods:</B> The cohort included 122 patients with clinically-documented RVOT-T. Regarding the demographic, electrocardiographic, structural, and invasive electrophysiological characteristics, several factors were explored to predict the cause of mortality, malignant ventricular arrhythmia, and implantable cardioverter defibrillator (ICD) implantation. <B>Results:</B> A total of 25 (20%) patients fulfilled the ARVD new Task Force (TF) criteria [TF(+)]. The mean follow-up duration was 48±39 months (range 3–120). Fifteen patients (12%) underwent ICD implantation [13 in TF(+)] for secondary prevention. All-cause mortality was noted in five patients [2 in TF(+)], and 8 had malignant ventricular arrhythmia [6 in TF(+)]. Malignant ventricular arrhythmia and mortality occurred in five TF(−) patients (4.1%). On multivariate analysis, independent predictors of events included hypertension (OR=6.32, P=0.043), left ventricular systolic dysfunction (OR=8.26, P=0.009). <B>Conclusion:</B> Without fulfilling the ARVC/D new TF criteria, patients with RVOT-T carried the risk of malignant ventricular arrhythmia and mortality. Hypertension and left ventricle systolic dysfunction (not the right ventricular dysfunction) are the predictors of long-term outcome in patients with RVOT-T.
著者
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HU Yu-Feng
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
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Li Cheng-hung
Division Of Cardiology Taipei Veterans General Hospital
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Lo Li-Wei
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Chao Tze-Fan
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Chao Tze-Fan
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
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Chung Fa-Po
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Chen Shih-Ann
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Chang Shih-Lin
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Hu Yu-Feng
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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Lin Yenn-Jiang
Division of Cardiology and Cardiovascular Research Center, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei Municipal Gan-Dau Hospital
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