Long-Term Outcome of Intensive Education as Treatment of Vasovagal Syncope: Median 3 Year Follow-Up

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Background: Treatment of vasovagal syncope has been not well established. We assessed the hypothesis that intensive education is effective. Methods: A total of 367 subjects who were diagnosed with vasovagal syncope by head-up tilt test from May 2006 to Dec. 2008 were investigated retrospectively. Group 1 (n=210) were treated with only intensive education. Group 2 (n=157) received conventional treatment of mediation plus simple explanation; beta-blocker (n=131), other (n=22). 312 subjects were interviewed with telephone during median 3 year follow-up and 53 visited regularly at outpatient clinic. The frequency of syncope episodes were divided into grade 0 (0 episode), grade 1 (1∼2), and grade 3 (3<). Results: Gender, diabetes history, the frequency of syncope were not different between group (p<0.05). Group 2 was older, had more hypertension, coronary disease than group 1. After a follow-up of 31±10 months, the frequency of syncope episodes after treatment reduced from grade 1.3±0.5 to grade 0.1±0.3 but 36 of 330 (11%) had syncope recurrence (grade 1.06±0.23). In multivariate regression analysis, young age (OR0.97, p=0.024) was an independent predictor of syncope recurrence and intensive education was not associated with increased risk of syncope. After propensity score analysis, intensive education was not associated with syncope recurrence. Conclusions: The efficacy of intensive education as treatment of vasovagal syncope was not different from that of conventional treatment.

Long-Term Outcome of Intensive Education as Treatment of Vasovagal Syncope: Median 3 Year Follow-Up

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