Carbohydrate-Binding Molecules with Non-Peptidic Skeletons

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概要

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• Emerging biological significance of carbohydrates has increased the importance of carbohydrate-binding molecules (CBMs) as diagnostic and therapeutic agents as well as research tools in glycobiology. Especially, there are rapidly growing interests in small molecules with a carbohydrate-binding property due to the ease of preparation and chemical modification. This minireview focuses on small-size CBMs that bind carbohydrates through non-covalent interactions. Small-size CBMs of synthetic origin have been progressively developed in the field of supramolecular chemistry. The representative architectures of the synthetic CBMs are briefly reviewed mainly focusing on recent examples. We also highlight naturally-occurring CBMs, pradimicins and its congeners. They are the only class of natural products with a lectin-like ability to recognize D-mannosides (Man) in the presence of Ca2+ ion. Our recent findings on molecular basis of their Man recognition are also described.

著者

• Nakagawa Yu

  Synthetic Cellular Chemistry Laboratory Riken Advanced Science Institute

• Ito Yukishige

  Synthetic Cellular Chemistry Laboratory Riken Advanced Science Institute

• Ito Yukishige

  Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

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