Acute Myeloid Leukemia with Myelodysplasia-related Changes Mimicking Acute Promyelocytic Leukemia

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概要

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• We describe a patient with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) that clinically resembled acute promyelocytic leukemia (APL). The karyotype of his leukemic cells was 46, XY, del (3) (q?) and did not include a chromosomal translocation involving the retinoic acid receptor-α gene. However, retinoic acid syndrome developed, and partial remission was achieved after treatment with all-trans retinoic acid (ATRA) followed by chemotherapy. Our case might provide new insights into the mechanism of the growth inhibitory effect of ATRA on APL-like cells.

著者

• Shinohara Tsutomu

  Department Of Pediatrics Kainan Hospital

• Hosokawa Emiko

  Division of Pulmonary Medicine, National Hospital Organization National Kochi Hospital, Japan

• Abe Shuichi

  Division of Pulmonary Medicine, National Hospital Organization National Kochi Hospital, Japan

• Ogushi Fumitaka

  Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

• Nakano Mayuri

  Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

• Okano Yoshio

  Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

• Hatakeyama Nobuo

  Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

• Iwahara Yoshihito

  Division of Internal Medicine National Hospital Organization National Kochi Hospital

• Machida Hisanori

  Division of Pulmonary Medicine National Hospital Organization National Kochi Hospital

• Naruse Keishi

  Division of Pathology National Hospital Organization National Kochi Hospital

• Shinohara Tsutomu

  Department of Clinical Investigation National Hospital Organization National Kochi Hospital

• Nakano Mayuri

  Division of Pulmonary Medicine, National Hospital Organization National Kochi Hospital, Japan

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