Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation

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概要

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• A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow. On day 20, the patient developed impaired consciousness and disorientation. Examination of the cerebrospinal fluid showed 2×104 copies/mL of HHV6B. HHV6 encephalitis was diagnosed, as had HHV6 myelitis based on symptoms that included lancinating pain/pruritus in the lower limbs and dysuria/dyschezia. Concurrently, he showed sinus tachycardia. Even after clearance of the HHV6 genome from the plasma and CSF was achieved by treatment with foscarnet, sinus tachycardia persisted for another 100 days. We suspected prolonged sinus tachycardia due to dysautonomia caused by HHV6 encephalomyelitis.

著者

• Hino Masayuki

  Hematology Graduate School Of Medicine Osaka City University

• Koh Hideo

  Hematology Graduate School Of Medicine Osaka City University

• Nakamae Mika

  Hematology Graduate School Of Medicine Osaka City University

• Terada Yoshiki

  Hematology Graduate School Of Medicine Osaka City University

• Nakane Takahiko

  Hematology Graduate School Of Medicine Osaka City University

• Nakamae Hirohisa

  Hematology Graduate School Of Medicine Osaka City University

• Nishimoto Mitsutaka

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Hayashi Yoshiki

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Yoshida Masahiro

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Bingo Masato

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Okamura Hiroshi

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Aimoto Mizuki

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Nanno Satoru

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Yoshimura Takuro

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Inaba Akiko

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Hagihara Kiyoyuki

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Hirose Asao

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Nakao Yoshitaka

  Hematology, Graduate School of Medicine, Osaka City University, Japan

• Nakane Takahiko

  Hematology, Graduate School of Medicine, Osaka City University, Japan

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• Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation
• Eosinophilia, Regardless of Degree, is Related to Better Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation

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