QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

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概要

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•   Objective  The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.  Methods  We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.  Patients  Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.  Results  LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD (r=0.35, p<0.01, r=0.43, p<0.01). Also left ventricular ejection fraction of (LVEF) or fractional shortening had a significant negative correlation to QTcD (r=−0.46, p<0.001, r=−0.27, p=0.02). The highest QTcD group had a significantly larger LV end-diastolic diameter or LV end-systolic diameter than the lowest QTcD [48.5±5.7 vs. 44.4±4.5 (mm), p<0.001, 34.1±6.4 vs. 28.8±4.3 (mm), p<0.001] and the highest QTcD group had a significantly lower LVEF than the lowest QTcD [57.5±8.0 vs. 65.5±6.4 (%), p<0.001]. On the other hand, none of the diastolic function markers were significantly correlated with QTcD.  Conclusion  We concluded that increased QTcD is correlated with LV dilation and systolic dysfunction induced by anthracycline therapy, and does not reflect a dispersion of ventricular repolarization or asynchronous motion.

• 社団法人　日本内科学会の論文
• 2004-05-01

著者

• Hino Masayuki

  Hematology Graduate School Of Medicine Osaka City University

• Hino Masayuki

  Clinical Hematology And Clinical Diagnosis Graduate School Of Medicine Osaka City University

• Tsumura Kei

  Department Of Hematology Fuchu Hospital

• Terada Yoshiki

  Hematology Graduate School Of Medicine Osaka City University

• Kaneko Mutsuo

  Fukuda Denshi Co, Ltd

• Okamoto Noboru

  Aichi ken Shokuin Hosp.

• Yamane Takahisa

  Hematology Graduate School Of Medicine Osaka City University

• NAKAMAE Hirohisa

  Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

• TSUMURA Kei

  Division of Cardiology, Graduate School of Medicine, Osaka City University

• AKAHORI Mika

  Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

• TERADA Yoshiki

  Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

• YAMANE Takahisa

  Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

• HAYASHI Takeo

  Fukuda Denshi Co., Ltd.

• SAITO Ikuko

  Fukuda Denshi Co., Ltd.

• ICHIHARA Yoshio

  Higashi Municipal Hospital of Nagoya

• OHTA Kensuke

  Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

• Nakamae Hirohisa

  Hematology Graduate School Of Medicine Osaka City University

• Saito Ikuko

  Fukuda Denshi Co. Ltd.

• Ohta Kensuke

  Department Of Hematology Osaka City University Graduate School Of Medicine Department Of Hematology

• Akahori Mika

  Clinical Hematology And Clinical Diagnostics Graduate School Of Medicine Osaka City University

• Kaneko Mutsuo

  Fukuda Denshi Co. Ltd.

• Okamoto Noboru

  Aichi Sannomaru Hospital

• Hayashi Takeo

  Fukuda Denshi Co. Ltd.

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