New-Onset Type 1 Diabetes Mellitus and Anti-Aquaporin-4 Antibody Positive Optic Neuritis Associated with Type 1 Interferon Therapy for Chronic Hepatitis C

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概要

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• A 60-year-old woman developed type 1 diabetes mellitus and anti-aquaporin-4 antibody positive optic neuritis during type 1 interferon therapies for chronic hepatitis C. The diabetes mellitus was elicited by interferon-α plus ribavirin therapy, while the optic neuritis was induced after interferon-β treatment, followed by interferon-α and ribavirin therapy. It is possible that type 1 interferons lead to the onset of the two autoimmune diseases by inducing disease-specific autoantibodies. Autoimmune disease is an infrequent complication of type 1 interferon treatment; however, once it has occurred, it may result in severe impairments. Patients undergoing type 1 interferon therapy should therefore be carefully monitored for any manifestations of autoimmune diseases.

著者

• Araki Manabu

  Department Of Immunology National Institute Of Neuroscience

• Wakakura Masato

  Inouye Eye Hospital

• KAWAZOE Tomoya

  Department of Gene Regulatorics, The Institute for Enzyme Research, The University of Tokushima

• Okamoto Tomoko

  Department Of Gastroenterology Hyogo Prefectural Tsukaguchi Hospital

• YAMAMURA Takashi

  Department of Applied Physics Faculty of Engineering, Tohoku University

• MURATA Miho

  Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)

• Ogawa Masafumi

  Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan

• Ogawa Masafumi

  Department of Neurology, National Center Hospital of Neurology and Psychiatry

• Murata Miho

  Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan

• Kawazoe Tomoya

  Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan

• Lin Youwei

  Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan

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