An Elderly Man with Syncytial Giant Cell Hepatitis Successfully Treated by Immunosuppressants

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概要

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• Here, we report an elderly man with acute-on-chronic hepatitis accompanied by massive ascites. He showed elevated serum transaminase and anti-nuclear antibody (ANA) levels. Liver biopsy showed diffuse multinucleated giant hepatocytes with interface hepatitis, and he recovered with administration of azathioprine in addition to corticosteroids. Follow-up liver biopsy after recovery showed improvement of hepatic inflammation and reduction of giant hepatocyte formation. The patient is receiving low-dose corticosteroid maintenance therapy and he has remained healthy for 8 years to date. Active immunosuppressive treatment may be beneficial in patients with adult syncitial giant cell hepatitis (AGCH).

著者

• SUGIYAMA TOSHIRO

  The Third Department of Internal Medicine Hokkaido University School of Medicine

• Shimizu Yukihiro

  Department Of Applied Physics Tohoku University

• Shimizu Yukihiro

  Department of Gastroenterology, Takaoka City Hospital, Japan

• Tajiri Kazuto

  The Third Department of Internal Medicine, University of Toyama, Japan

• Tokimitsu Yoshiharu

  The Third Department of Internal Medicine, University of Toyama, Japan

• Tsuneyama Koichi

  The First Department of Pathology, University of Toyama, Japan

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