Sub-acute Demyelinating Polyradiculoneuropathy as an Initial Symptom of Peripheral T Cell Lymphoma, Not Otherwise Specified (PTCL-NOS)

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概要

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• Here we report the first case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), who initially presented with peripheral neuropathy. Nerve conduction, cerebral spinal fluid studies and his clinical course were compatible with sub-acute demyelinating polyradiculoneuropathy. In addition, left cervical lymph node swelling was observed on admission. Diagnosis of PTCL-NOS was made by the histological, immunohistochemical, and Southern blot analyses on the biopsy specimen from the enlarged lymph node. Combination chemotherapy composed of cyclophosphamide, vincristine, doxorubicin and prednisolone (CHOP) was effective for polyneuropathy as well as for lymphoma. Several antibodies relating to paraneoplastic syndrome such as Ma1, Ma2, Amphiphysin, CV2, Ri, Yo and Hu were all negative. Because sural nerve biopsy performed prior to CHOP therapy revealed no infiltration of lymphoma cells, immune dysfunction mediated by some cytokine or unidentified autoantibody related to PTCL-NOS was thought to be involved in the polyradiculoneuropathy.

著者

• Kawanishi Kazunobu

  Division Of Hematology Nephrology And Rheumatology Department Of Internal Medicine Kinki University

• Miyatake Junichi

  Division Of Hematology Nephrology And Rheumatology Department Of Internal Medicine Kinki University

• Tanaka Hirokazu

  Divison Of Biological Science Graduate School Of Science Nagoya University

• Matsumura Itaru

  Division Of Hematology Department Of Internal Medicine Kinki University Faculty Of Medicine

• Nakamine Hirokazu

  Pathology And Immunology Division Kansai University For Medical Sciences

• Ashida Takashi

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Hirase Tikara

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Ohyama Yasuyo

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Kanai Yoshitake

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Tatsumi Youichi

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Kawanishi Kazunobu

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Miyatake Junichi

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

• Matsumura Itaru

  Division of Hematology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Kinki University, Japan

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