Peripartum Cardiomyopathy Presenting with Syncope due to Torsades de Pointes: a Case of Long QT Syndrome with a Novel KCNH2 Mutation
スポンサーリンク
概要
- 論文の詳細を見る
Peripartum cardiomyopathy (PPCM) is a cardiomyopathy of unknown cause that occurs in the peripartum period. We report a case of PPCM presenting with syncope 1 month after an uncomplicated delivery. Electrocardiography showed Torsades de pointes (TdP) and QT interval prolongation. Echocardiography showed left ventricular systolic dysfunction and endomyocardial biopsy showed myocyte degeneration and fibrosis. Administration of magnesium sulfate and temporary pacing eliminated recurrent TdP. Genetic analyses revealed that recurrent TdP occurred via electrolyte disturbance and cardiac failure due to PPCM on the basis of a novel mutation in KCNH2, a gene responsible for inherited type 2 long QT syndrome.
著者
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Nishiyama Hirohiko
Department Of Cardiology National Hospital Organization Kure Medical Center
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Tamura Ritsu
Department Of Cardiology National Hospital Organization Kure Medical Center
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Taniyama Kiyomi
Department Of Clinical Laboratory Pathology Division National Hospital Organization Kure Medical Cen
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Nishimoto Orie
Department Of Cardiology National Hospital Organization Kure Medical Center
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Matsuda Morihiro
Department Of Cardiology National Hospital Organization Kure Medical Center
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Shimizu Wataru
Division Of Arrhythmia And Electrophysiology Department Of Cardiology National Cerebral And Cardiova
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Kawamoto Toshiharu
Department Of Cardiology National Hospital Organization Kure Medical Center
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Kuraoka Kazuya
Department Of Diagnostic Pathology National Hospital Organization Kure Medical Center And Chugoku Ca
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Nakamoto Kei
Department of Cardiology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan
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Kawamoto Toshiharu
Department of Cardiology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan
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Matsuda Morihiro
Department of Cardiology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan
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Nishiyama Hirohiko
Department of Cardiology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan
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