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Hemodynamic studies using radiocardiocardiography with radioactive iodinated human serum albumin [RIHSA] were performed in thirty-four patients with essential hypertension before and during treatment with oral arotinolol, bunazosin and prazosin, and these effects were compared with those in twenty-one patients treated with propranolol and labetalol in a previous study<BR>α-Blockade with bunazosin and prazosin decreased systolic and diastolic blood pressure without any significant change in cardiac index (CI), and tended to reducetotal peripheral resitance index (TPRI). α, β-Blockade with labetalol tended to reduce heart rate and reduced TPRI without any change in CI. α, β-Blockade with arotinolol, which had weaker α-blocking activity than labetalol, reduced systolic and diastolic blood pressure, heart rate and CI, and increased TPRI. These effects appeared to be similar to those of β-blockade with propranolol . However, the increase in TPRI with propranolol was greater than that with arotinolol.<BR>These results suggest that vascular β-receptor blocking action may play a part in increasing peripheral resistance, while the α-blocking action on vascular sites may induce vasodilating action with a resultant decrease in TPRI or minimize elevated TPRI with vascular β-blockade according to their potency of the α-blocking activity.
一般社団法人日本臨床薬理学会の論文