Study of amikacin sulfate-impregnated bone cement on total knee replacement.

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The excretion pharmacokinetics of following total knee replacement with amikacinimpregnated bone cement was studied in 23 cases and 25 joints. The patients received 2 g of amikacin. Measurments of the amikacin concentration in drainage (2 hr, 4 hr, 24 hr, and 48 hr after operation) were carried out in all cases. Amikacin excretion-time curve was rapid during the initial phase lasting until 48 hours after operation. The concentration of amikacin in the knee joint was 5.73±0.81μg/ml at the 7 th day after operation and 1.28±0.16μg/ml at the 14 th day. The concentration of amikaicn on the 7 th day covered the MICs of <I>Staphylococcus aureus, E. coli, and Pseudomonas aeruginosa.</I>Amikacin-impregnated cement is thus considered useful for prophylactic treatment when total joint arthroplasties are operated upon.