Hemodynamic effects of intravenous cibenzoline, a new antiarrhythmic agent.

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Hemodynamic effects of intravenous cibenzoline administration were studied in 16 patients with various arrhythmias using Swan-Ganz catheter method.<BR>1) Cibenzoline injection produced slight decrease in heart rate and cardiac index, and slight increase in pulmonary capillary wedge pressure and systemic vascular resistance. In patients with acute myocardial infarction, the decrease in cardiac index and the increase in diastolic blood pressure and systemic vascular resistance were statistically significant.<BR>2) Nine out of the 15 patients responded successfully to cibenzoline injection. However, aggravation of arrhythmia was observed in 3 patients.<BR>3) Hypotension with vomiting occurred in 1 patient.<BR>In conclusion, intravenous cibenzoline exerts slight, but significant negative inotropic effects. It must be used with caution in patients with depressed left ventricular function.
一般社団法人日本臨床薬理学会の論文