Pharmacokinetics of long-acting capsule of carteolol hydrochloride in a repeated study.
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Pharmacokinetics of long-acting (LA) capsule of carteolol hydrochloride were investigatedin healthy adult male volunteers. The LA group received 15 mg/person once daily whilethe comparison group received conventional tablets (CT), 5 mg/person, three times a day, for 9 days of repeated administration.<BR>The plasma concentrations of both the LA and CT groups reached a steady-state on Day3.<BR>Although the pharmacokinetic parameters, AUC, C<SUB>max</SUB>, C<SUB>min</SUB>, and C<SUB>max</SUB>/C<SUB>min</SUB> in the steadystaterevealed no significant differences between the two groups, t<SUB>1/2</SUB> was significantlydifferent between LA (9.3hr), and CT (6.9hr).<BR>The plasma concentration profile on the LA repeated adminitsration corresponded wellto the prediction curves estimated from the LA single administration study. T<SUB>1/2</SUB> in thesteady-state of LA dosing was quite similar to that of a single adminitsration of LA. Thesefacts reveal that the prolongation of plasma concentration maintained by LA administrationdid not cause any accumulation of carteolol nor any change in the pharmacokinetics.<BR>In conclusion, a once-daily administration by LA capsule is proposed as being clinicallyuseful.
- 一般社団法人 日本臨床薬理学会の論文
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- Pharmacokinetics of long-acting capsule of carteolol hydrochloride in a repeated study.
- 塩酸ブプレノルフィン坐剤の臨床第1相試験
- Pharmacokinetics and pharmacodynamics of long-acting capsule of carteolol hydrochloride.