Clinical Evaluation by a Double Blind Controlled Study with Desoximetasone, a Topical Corticosteroid:Examination of Optimal Concentration

スポンサーリンク

概要

• 論文の詳細を見る

• A double blind controlled study was conducted to compare the efficacy of 0.25% desoximetasone and 0.05% desoximetasone. 72 patients with the same skin lesion (acute eczema-like dermatitis or atopic dermatitis) on both sides of the body were selected for the study. One preparation was randomly chosen to be applied to the right side and the other was then applied to the left side two or three times a day. No occlusion was used. The data collected according to the degree of general improvement in each patient's skin condition, the posttreatment severity of his symptoms and the degree of utility was analyzed by the analysis of variance method. Data concerning relative effectiveness and relative utility was analyzed by Scheffë's paired comparison method.<BR>For patients with acute eczema-like dermatitis, 0.25% desoximetasone proved to be statistically superior to 0.05% desoximetasone in such evaluation items as relative effectiveness, relative utility and posttreatment papule severity. With atopic dermatitis patients, no significant difference between the two concentrations was noted in any of the evaluation items.<BR>Neither of the two concentrations produced any side effects. Both preparations proved to have an excellent therapeutic effect. 0.25% desoximetasone is considered to be more useful than the 0.05% concentration, however, particularly when the two preparations are used against the early stages of eczematous dermatitis.

• 一般社団法人 日本臨床薬理学会の論文

著者

• 吉田 貞夫

  横浜南共済病院皮膚科

• 杉田 暉道

  横浜市立大学医学部公衆衛生学教室

• 高梨 雄藏

  国立相模原病院皮膚科

• 柳田 英夫

  田浦共済病院皮膚科

関連論文

• 尋常性〓瘡に対するアクアチム^【○!R】クリームとイオウ製剤との併用療法
• 127 チメロサールアレルギーの検討
• 各種皮膚潰瘍に対するベラプロストナトリウム(ドルナー^【○!R】)の治療効果の検討
• 感染性褥瘡および感染性皮膚潰瘍に対するユーパスタコーワ^【○!R】の有用性の検討
• 133.トリコフィチン皮膚反応に関する免疫組織学的検討(皮膚アレルギー)
• 48.蚊によるアレルギーの1例(皮膚疾患とアレルギー(II))
• ヒト型結核菌抗酸菌ファージK1 ,S1に対する感受性
• 学童の血圧の棄却楕円による検討〔英文〕
• Clinical Evaluation by a Double Blind Controlled Study with Desoximetasone, a Topical Corticosteroid:Examination of Optimal Concentration
• Immunohistologic study of mammary and extramammary Paget's disease and apocrine series and ecrine series tumor.

スポンサーリンク