硫黄泉の生化学的作用に関する実験的研究-2-肝障害ラットに対する硫黄泉飲用の効果

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The effect of oral administration of sulphur hot spring water on chronic liver damaged rat was studied. The liver damaged rats were produced by injection of carbon tetrachloride (150l of CCl4 per 100g of body weight) twice a week. Sulphur hot spring water was administrated ad libitum as drinking water throughout experimental period. At 40 and 88 days, rats were sacrificed for histological and biochemical examinations.When tap water was administrated to CCl4-poisoning rats for 88 days, extensive vacuolar degeneration of parenchymal cells were observed in liver. While in administration of sulphur hot spring water, there were mild vacuolar degeneration in parenchymal cells of liver.Although GSH content and GSH-peroxidase activity of liver unchanged in CCl4-poisoning, and were unaffected with administration of sulphur hot spring water, GSH-reductase activity increased with administration of sulphur hot spring water for 88 days. The increased lipoperoxide and hydroxyproline in liver with CCl4-poisoning were slightly lowered by administration of hot spring water.In plasma, furthermore, LDH, GPT and GOT activities which increased markedly by CCl4-poisoning decreased strikingly by administration of hot spring water at 88 days. Whereas ALP, CE and LAP activities little changed by CCl4-poisoning, and were scarcely affected with administration of hot spring water. Among other plasma components, though total cholesterol and cholesteryl ester levels decreased by CCl4-poisoning, those levels were not sustained with sulphur hot spring water administration.
一般社団法人日本温泉気候物理医学会の論文

硫黄泉の生化学的作用に関する実験的研究-2-肝障害ラットに対する硫黄泉飲用の効果

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