Effects of a New Anti-inflammatory, Analgesic and Antipyretic Drug MK-647 (Diflunisal) on Healthy Japanese Volunteers

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A new anti-inflammatory, analgesic and antipyretic drug MK-647 was given orally in varying doses to a total of thirteen healthy Japanese volunteers for the observation of its influence on the findings of their physiological functions, heamtological tests, urinary analysis and sero-biochemical tests. At the same times, surveys were made on the changes produced in its blood level, urinary excretion and analgesic effects.<BR>As the result, no abnormality was observed on the physiological functions except an increase in the bowel sound provided the dosage employed was below 500mg at a time. This enhancement of the bowel sound, however, indicates a possibility for the development of gastrointestinal side effects.<BR>As for laboratory tests, an increase in alkaline phophatase was observed. A care should be taken on this matter when carrying out clinical studies in the future.<BR>Accumulation may be negated in view of the change in its blood level, however. Compared with acetylsalicylic acid, its effect was rather delayed in onset and lasted longer. Satisfactory clinical effect may be expected with administration twice a day.
一般社団法人日本臨床薬理学会の論文