人工塩類泉バスクリンの効果に関する研究--循環動態,深部体温,自律神経機能,血液ガスの変化について

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The effects of single bathing of the artificial mineral spring (Basukurin: Tsumura Juntendo Inc. Japan), equivalent mixture of sodium sulfate and sodium bicarbonate, were studied in 13 normal and 22 hypertensive subjects comparing with natural simple hot spring (Kirisima spa).Blood pressure (BP: automatic sphygmomanometer), heart rate (HR), cardiac output (CO: earpiece type dye-dilution densisometer), total peripheral resistance (TPR: mean BP/cardiac index), forehead deep body temperature (DBT: Core Temp CTM 204) plasma renin activity (PRA: RIA by Habar's method), plasma norepinephrine (NE) and blood gas partial pressure (pO2 and pCO2) and pH were measured before and after bathing. Mineral concentration of simple hot spring and Basukurin bath (120g powder/360l simple hot spring) were 0.019% and 0.052%, respectively. The temperature and duration of bathing were both 41°C for 10min.In normotensives, only systolic BP and TPR were significantly decreased 30min after the simple and Basukurin bathing by the same degree. HR was significantly increased throughout 30min after both bathing. CO was increased only after 10min of Basuku rin bathing. In hypertensives, systolic and diastolic BP and TPR were significantly decreased throughout 30min after simple and Basukurin bathing. The decrement in BP and TPR, however were significantly greater in Basukurin bathing. HR and CO were significantly increased after both bathing. Forehead DBT was significantly elevated after both bathing and gradually decreased throughout 30min of observation. In Basukurin bathing, although the increment in DBT was greater than simple hot spring bathing, the decrease was slower than simple hot spring bathing suggsting the protection from heat radiation by Basukurin bathing. PRA and plasma NE concentration examined in hypertensive subjects after 30min of bathing were significantly elevated only in Basukurin bathing. Although arterial gas concentration and pH were not changed after bathing, venous blood pO2 and pH were significantly increased and pCO2 was significantly decreased after 10min of Basukurin bathing.These data indicates that single Basukurin bathing has more potent hypotensive effect due to vasodilation than simple hot spring. Enhanced vasodilation by Basukurin bathing is probably derived from the protection of heat radiation from the skin by the formtion of thin mineral film on the skin. Increased venous blood pO2 and pH and decreased pCO2 represents also the improvement of peripheral circulation assisted by vasodilation and elevated CO.
一般社団法人日本温泉気候物理医学会の論文

人工塩類泉バスクリンの効果に関する研究--循環動態,深部体温,自律神経機能,血液ガスの変化について

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