Analysis of intestinal motility by enteric sound recording system - Clinical evaluation of aclatonium napadisilate and prostaglandine F2.ALPHA. on intestinal movement.:CLINICAL EVALUATION OF ACLATONIUM NAPADISILATE AND PROSTAGLANDINE F2α ON INT

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In patients with so-called postopeartive enteroplegia after laparotomy, effects of aclatonium napadisilate (abbreviated as TM-723 hereinafter) and prostaglandine F2α (abbreviated as PGF2α) on intestinal motility were determined using an entericsound recording system (phonointestinography) and simultaneously the time required for breaking wind after operation was examined. 1. TM-723 wasadministeredat a dose of 50 mg from the intestinal fistula after dissolved in 5ml of physiological saline, while PGF2α was administered as an i.v. drip infusionat a dose of 2 mg dissolved in 500 ml of 5% glucose solution. Intestinal movement was determined at McBurney point using the enteric sound recording systemdeveloped at our department. 2. The time required for breaking wind after operation was determined in three groups received TM-723, PGF2α and placebo, respectively. No significantintergroup difference was observed. 3. As to effect on intestinal motility, TM-723 increased intestinal motility when it was reduced in so-called postoperative enteroplegia phase. Its efficacy became higher with a decrease in motility. On the contrary, TM-723 rather tended to depress intestinal motility when it was increased. On the other hand, PGF2α tendedto increase intestinal motility regardless of motility in enteroplegia phase.
日本平滑筋学会の論文