Relationship between blood pressure and smooth muscle tone in aortae of hypertensive rats: roles of (Ca2+).
スポンサーリンク
概要
- 論文の詳細を見る
Spontaneously developed tension (active tone) and intracellular Ca<SUP>2+</SUP> level of aortae from spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), malignant SHRSP (M-SHRSP) and control Wistar Kyoto rats (WKY) were compared. Systolic blood pressure of WKY, SHR, SHRSP and M-SHRSP was 130mmHg, 200mmHg, 250mmHg and 260mmHg, respectively. Preparations from all strains of spontaneously hypertensive rats exhibited active tone which was abolished by the removal of extracellular Ca<SUP>2+</SUP> or by the application of verapamil. The active tone was greater in the order of aortae from SHR<SHRSP<M-SHRSP. Intracellular Ca<SUP>2+</SUP> level measured by Fura-2 method decreased by the removal of extracellular Ca<SUP>2+</SUP>. The degree of the decrease was greater as the blood pressure of the rats increased, indicating the greater elevation of intracellular Ca<SUP>2+</SUP> level in the presence of extracellular Ca<SUP>2+</SUP>. A correlation was obtained between the active tone, intracellular Ca<SUP>2+</SUP> level and blood pressure. Thus, it was demonstrated that the development of the active tone is brought about by the changes in Ca<SUP>2+</SUP> influx of smooth muscle cell membrane and the degree of the change is positively related to the degree of hypertension.
- 日本平滑筋学会の論文
著者
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Shimamura K.
Research Institute of Hypertension, Kinki University
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SASAKI Fumiko
Faculty of Pharmaceutical Sciences, Kinki University
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OSUGI S.
Research Institute of Hypertension, Kinki University
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SUNANO S.
Faculty of Pharmaceutical Sciences, Kinki University
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