Comparison of Endothelium-dependent and -independent Tension Oscillation in Aortae of Stroke-Prone Spontaneously Hypertensive Rats and Wistar Kyoto Rats.
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概要
- 論文の詳細を見る
Differences in noradrenaline-induced tension oscillations between aortae from strokeprone spontaneously hypertensive rats (SHRSP) and normotensive control Wistar Kyoto rats (WKY) were studied. Endothelium-intact and -removed ring preparations were made from thoracic aorta of SHRSP and WKY, and isometric contraction was observed. Endothelium-intact preparations from WKY showed tension oscillations in response to high concentration of noradrenaline at significantly higher ratio, while only a few endotheliumremoved preparation showed tension oscillations in response to low concentration of the drug. Fifteen out of 41 endothelium-removed preparations from SHRSP showed tension oscillations in response to low concentration of noradrenaline but no preparation showed oscillations in response to high concentration of the drug. Seven and 14 out of 42 endothelium-intact preparations from SHRSP showed oscillatory response to low and high concentration of the drug, respectively. Acetylcholine-induced relaxation and tension oscillations, both of which being significantly less in the preparation from SHRSP. Both the endothelium-independent tension oscillations and endothelium-dependent tension oscillations were abolished by removal of extracellular Ca or by verapamil. It is suggested that aortic smooth muscle of SHRSP possesses the property which produced tension oscillations, while the tension oscillations of WKY aorta is endothelium-dependent. The opening of voltagedependent Ca++ channel of smooth muscle cell membrane which generates rhythmic contraction is increased in the aorta of SHRSP, while the release of endothelium-derived factors which induces rhythmic activities of smooth muscle cell is decreased.
- 日本平滑筋学会の論文
著者
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SHIMAMURA Keiichi
Research Institute of Hypertension, Kinki University
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Sunano Satoru
Research Institute of Hypertension, Kinki University
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Osugi Shoko
Research institute of hypertension, Kinki university
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SASAKI Fumiko
Faculty of Pharmaceutical Sciences, Kinki University
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Sunano Satoru
Research Institute of Hypertension
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